What Is CBC Blood Test? Complete Blood Count

cbc blood test

 

What Is CBC Blood Test and its Components? 

The CBC blood test, also known as a complete blood count (CBC) blood test, is a blood test that measures various components of the blood, including red blood cells, white blood cells, and platelets. It can provide information about a person’s overall health and can help diagnose a variety of conditions, such as anemia, infection, and leukemia. The test typically includes measurements of hemoglobin, hematocrit, red blood cell count, and platelet count. Other parameters such as mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) may also be included.

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CBC Blood Components

WHAT IS THE TOTAL LEUKOCYTE COUNT (WBC)?

Total leukocyte count (WBC): This is a measurement of the total number of white blood cells in a given volume of blood. White blood cells are an important part of the body’s immune system. It plays a key role in fighting infections and diseases. An abnormal WBC count can indicate an underlying health condition, such as an infection, inflammation, or leukemia. The normal range for WBC count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 4,000 to 11,000 cells per microliter of blood.

What are Neutrophils?

Neutrophils: A type of white blood cell that plays an important role in the body’s immune system. They are the most abundant type of white blood cell and are primarily responsible for fighting off bacterial infections. Neutrophils work by engulfing and destroying invading bacteria and other pathogens. An increase in neutrophil count, known as neutrophilia, can be a sign of an infection or inflammation, while a decrease in neutrophil count, known as neutropenia, can increase the risk of infections. The normal range of neutrophil count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 40% to 60% of the total white blood cell count.

WHAT IS LYMPHOCYTE PERCENTAGE?

The lymphocyte percentage: This is a measurement of the proportion of white blood cells in the blood that are lymphocytes, which are a type of immune cell. Lymphocytes play a critical role in the body’s immune response and are responsible for recognizing and attacking foreign substances such as viruses, bacteria, and cancer cells. An increase or decrease in lymphocyte percentage can indicate an underlying health condition or infection. For adults, the normal range of lymphocyte percentage typically ranges from 20% to 40% of the total white blood cell count, but this may vary depending on the laboratory and the individual’s age, sex, and other factors.

What are Monocytes?

Monocytes: These are a type of white blood cell that plays an important role in the body’s immune system. They are responsible for engulfing and digesting dead or damaged cells, as well as attacking and destroying invading bacteria and other pathogens. Monocytes can also help stimulate the production of other immune cells. An increase in monocyte count, known as monocytosis, can be a sign of an infection or chronic inflammatory condition, while a decrease in monocyte count can indicate a weakened immune system. The normal range of monocyte count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 2% to 10% of the total white blood cell count.

WHAT ARE EOSINOPHILS?

Eosinophils: Are a type of white blood cell that is involved in the body’s immune response to allergies and parasitic infections. They work by releasing chemicals that help to kill parasites and also play a role in regulating inflammation in the body. An increase in eosinophil count, known as eosinophilia, can be a sign of an allergic or parasitic condition, while a decrease in eosinophil count is generally not considered clinically significant. The normal range of eosinophil count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 1% to 6% of the total white blood cell count.

What are Basophils?
Basophils: A type of white blood cell that is involved in the body’s immune response to allergic reactions and certain infections. They contain granules that release histamine and other chemicals in response to allergens or inflammation. Basophils play a role in the body’s immediate hypersensitivity reactions, which can cause symptoms such as itching, hives, and swelling. An increase in basophil count, known as basophilia, is rare and may be a sign of certain conditions such as myeloproliferative neoplasms or chronic infections. The normal range of basophil count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 0.5% to 1% of the total white blood cell count.

WHAT IS IMMATURE GRANULOCYTE PERCENTAGE (IG%)?

The immature granulocyte percentage (IG%): This is a measurement of the proportion of white blood cells in the blood that are immature granulocytes, which include metamyelocytes, myelocytes, and promyelocytes. These cells are normally found in the bone marrow and are released into the bloodstream in response to infection or inflammation. An increase in IG%, also known as a left shift, can be a sign of an acute bacterial infection or other inflammatory condition. The normal range of IG% may vary depending on the laboratory and the individual’s age, sex, and other factors, but is typically less than 1-3% of the total white blood cell count.

What is Neutrophils’ absolute count?

Neutrophils absolute count: is a measurement of the actual number of neutrophils present in a given volume of blood. This count is obtained by multiplying the total white blood cell count by the percentage of neutrophils present in the blood (obtained from a differential white blood cell count test). An increase in the neutrophil absolute count can be a sign of bacterial infection, inflammation, or other conditions that stimulate the production or release of neutrophils from the bone marrow. The normal range for neutrophil absolute count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 2,500 to 7,000 cells per microliter of blood.

WHAT IS THE LYMPHOCYTE ABSOLUTE COUNT?

Lymphocytes absolute count: is a measurement of the actual number of lymphocytes present in a given volume of blood. This count is obtained by multiplying the total white blood cell count by the percentage of lymphocytes present in the blood (obtained from a differential white blood cell count test). An increase or decrease in the lymphocyte absolute count can be an important diagnostic clue in various conditions. For example, an increase in the lymphocyte absolute count may be seen in viral infections or some types of leukemia, while a decrease may be seen in immunodeficiency disorders. The normal range for lymphocyte absolute count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 1,000 to 4,800 cells per microliter of blood.

WHAT IS THE  MONOCYTES ABSOLUTE COUNT?

Monocytes absolute count: is a measurement of the actual number of monocytes present in a given volume of blood. This count is obtained by multiplying the total white blood cell count by the percentage of monocytes present in the blood (obtained from a differential white blood cell count test). An increase in the monocyte absolute count, known as monocytosis, can be a sign of chronic infections, inflammatory conditions, autoimmune disorders, and some types of cancers. A decrease in the monocyte absolute count is not typically considered clinically significant. The normal range for monocyte absolute count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 200 to 800 cells per microliter of blood.

What is Basophils absolute count ?

Basophils absolute count: is a measurement of the actual number of basophils present in a given volume of blood. This count is obtained by multiplying the total white blood cell count by the percentage of basophils present in the blood (obtained from a differential white blood cell count test). An increase in the basophil absolute count, known as basophilia, is rare and may be a sign of certain conditions such as myeloproliferative neoplasms or chronic infections. The normal range for basophil absolute count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 10 to 100 cells per microliter of blood.

WHAT IS EOSINOPHILS ABSOLUTE COUNT?

Eosinophils absolute count: is a measurement of the actual number of eosinophils present in a given volume of blood. This count is obtained by multiplying the total white blood cell count by the percentage of eosinophils present in the blood (obtained from a differential white blood cell count test). An increase in the eosinophil absolute count, known as eosinophilia, can be a sign of allergies, parasitic infections, autoimmune diseases, or certain types of cancers. The normal range for eosinophil absolute count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 30 to 350 cells per microliter of blood.

What is Immature granulocytes (IG)?
Immature granulocytes (IG): are a group of white blood cells that include metamyelocytes, myelocytes, and promyelocytes. These cells are released into the bloodstream in response to infection or inflammation and are not typically present in significant numbers in the peripheral blood of healthy individuals. An increase in the percentage of immature granulocytes, known as a left shift, can be a sign of an acute bacterial infection or other inflammatory condition. Immature granulocytes can be identified and quantified using a differential white blood cell count test, and the normal range for immature granulocytes may vary depending on the laboratory and the individual’s age, sex, and other factors, but is typically less than 1-3% of the total white blood cell count.

WHAT IS THE TOTAL RBC (RED BLOOD CELL) COUNT?

Total RBC (red blood cell) count: this is a measurement of the total number of red blood cells in a given volume of blood. Red blood cells are responsible for carrying oxygen from the lungs to the body’s tissues and removing carbon dioxide. The RBC count can be obtained from a complete blood count (CBC) test. The normal range for RBC count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 4.5 to 5.5 million cells per microliter of blood in adult males and from 4.0 to 5.0 million cells per microliter of blood in adult females. A decrease or increase in RBC count can indicate various health conditions, such as anemia, polycythemia, kidney disease, or bone marrow disorders.
What are Nucleated red blood cells (nRBCs) ?

Nucleated red blood cells (nRBCs): are immature red blood cells that still contain a nucleus. These cells are typically only found in the bone marrow and are not normally present in the peripheral blood of healthy individuals. The presence of nRBCs in the peripheral blood can indicate that the bone marrow is responding to increased demand for red blood cell production, such as in anemia or blood loss. nRBCs can be identified and counted using a blood smear and microscopic examination. The normal range for nRBCs in the peripheral blood is typically less than 1 per 100 white blood cells. However, the normal range may vary depending on the laboratory and the individual’s age, sex, and other factors.

WHAT ARE NUCLEATED RED BLOOD CELLS (NRBCS)?

The nucleated red blood cells (nRBCs): percentage is the proportion of nRBCs to the total number of white blood cells observed on a blood smear. This measurement can provide an estimate of the number of nRBCs in the peripheral blood and is useful in assessing the degree of erythropoietic activity in the bone marrow. The presence of nRBCs in the peripheral blood can indicate that the bone marrow is responding to increased demand for red blood cell production, such as in anemia or blood loss. The normal range for nRBC percentage in the peripheral blood is typically less than 1% of white blood cells. However, the normal range may vary depending on the laboratory and the individual’s age, sex, and other factors.
What is Hemoglobin (Hb)? 
Hemoglobin (Hb): is a protein in red blood cells that carries oxygen from the lungs to the body’s tissues and removes carbon dioxide. Hemoglobin is measured in grams per deciliter (g/dL) of blood, and the measurement is typically obtained from a complete blood count (CBC) test. The normal range for hemoglobin may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 13.5 to 17.5 g/dL in adult males and from 12.0 to 15.5 g/dL in adult females. A decrease or increase in hemoglobin level can indicate various health conditions, such as anemia, dehydration, sickle cell disease, or polycythemia.

WHAT IS HEMATOCRIT (PCV)?

HEMATOCRIT (PCV): also known as packed cell volume (PCV), is a measurement of the proportion of red blood cells in the total volume of blood. It is typically expressed as a percentage. The hematocrit measurement is obtained from a complete blood count (CBC) test. The normal range for hematocrit may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 38.8% to 50% in adult males and from 34.9% to 44.5% in adult females. A decrease or increase in hematocrit level can indicate various health conditions, such as anemia, dehydration, blood loss, or polycythemia.

What is Mean corpuscular volume (MCV)?
Mean corpuscular volume (MCV): is a measurement of the average size of red blood cells in a given volume of blood. MCV is typically reported in femtoliters (fL). The MCV measurement is obtained from a complete blood count (CBC) test. The normal range for MCV may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 80 to 100 fL. A low MCV indicates that the red blood cells are smaller than normal, which can occur in conditions such as iron deficiency anemia or thalassemia, while a high MCV indicates that the red blood cells are larger than normal, which can occur in conditions such as vitamin B12 deficiency anemia or liver disease.

WHAT IS MEAN CORPUSCULAR HEMOGLOBIN (MCH)?

Mean corpuscular hemoglobin (MCH): is a measurement of the average amount of hemoglobin in a single red blood cell. MCH is typically reported in picograms (pg). The MCH measurement is obtained from a complete blood count (CBC) test. The normal range for MCH may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 27 to 32 pg. A low MCH value may indicate a type of anemia, such as iron deficiency anemia or thalassemia, while a high MCH value may indicate a type of anemia, such as pernicious anemia, or other conditions, such as liver disease. However, MCH is usually interpreted in conjunction with other CBC parameters to provide a more comprehensive understanding of a patient’s health status.

What is Mean corpuscular hemoglobin concentration (MCHC)?
Mean corpuscular hemoglobin concentration (MCHC): is a measurement of the average concentration of hemoglobin in a given volume of red blood cells. MCHC is typically reported as a percentage. The MCHC measurement is obtained from a complete blood count (CBC) test. The normal range for MCHC may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 32% to 36%. A low MCHC value may indicate a type of anemia, such as iron deficiency anemia or thalassemia, while a high MCHC value is rare and may indicate conditions such as hereditary spherocytosis or hemolytic anemia. However, MCHC is usually interpreted in conjunction with other CBC parameters to provide a more comprehensive understanding of a patient’s health status.

WHAT IS RED CELL DISTRIBUTION WIDTH – SD(RDW-SD)?

Red cell distribution width – standard deviation (RDW-SD): is a measure of the variation in the size of red blood cells. It is typically reported in femtoliters (fL). RDW-SD is one of the parameters that can be obtained from a complete blood count (CBC) test. The normal range for RDW-SD may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 35 to 47 fL. An increased RDW-SD value may indicate a higher degree of variability in the size of red blood cells, which can be seen in conditions such as iron deficiency anemia, vitamin B12 or folate deficiency, or hemolytic anemia. However, RDW-SD is usually interpreted in conjunction with other CBC parameters to provide a more comprehensive understanding of a patient’s health status.
What is RED CELL DISTRIBUTION WIDTH (RDW-CV)?

Red cell distribution width – coefficient of variation (RDW-CV): is a measure of the variation in size of red blood cells. It is typically reported as a percentage. RDW-CV is one of the parameters that can be obtained from a complete blood count (CBC) test. The normal range for RDW-CV may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 11.5% to 14.5%. An increased RDW-CV value may indicate a higher degree of variability in the size of red blood cells, which can be seen in conditions such as iron deficiency anemia, vitamin B12 or folate deficiency, or hemolytic anemia. However, RDW-CV is usually interpreted in conjunction with other CBC parameters to provide a more comprehensive understanding of a patient’s health status.

WHAT IS PLATELET DISTRIBUTION WIDTH (PDW)?

Platelet distribution width (PDW): is a measure of the variation in the size of platelets in a blood sample. It is typically reported as a percentage. PDW is one of the parameters that can be obtained from a complete blood count (CBC) test. The normal range for PDW may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 9.9% to 17.1%. An increased PDW value may indicate a higher degree of variation in the size of platelets, which can be seen in conditions such as immune thrombocytopenia, myelodysplastic syndrome, or other platelet disorders. However, PDW is usually interpreted in conjunction with other CBC parameters and clinical information to provide a more comprehensive understanding of a patient’s health status.
What is Mean platelet volume (MPV)?
Mean platelet volume (MPV): is a measure of the average size of platelets in a blood sample. It is typically reported in femtoliters (fL). MPV is one of the parameters that can be obtained from a complete blood count (CBC) test. The normal range for MPV may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 7.4 to 10.4 fL. An increased MPV value may indicate a higher degree of platelet activation, which can be seen in conditions such as immune thrombocytopenia, myelodysplastic syndrome, or other platelet disorders. However, MPV is usually interpreted in conjunction with other CBC parameters and clinical information to provide a more comprehensive understanding of a patient’s health status.

WHAT IS PLATELET COUNT?

Platelet count: This is a laboratory test that measures the number of platelets in a person’s blood. Platelets are small, colorless cell fragments that help the blood to clot and prevent excessive bleeding. The normal range for platelet count may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 150,000 to 450,000 platelets per microliter of blood. An abnormally low platelet count (thrombocytopenia) may increase the risk of bleeding, while an abnormally high platelet count (thrombocytosis) may increase the risk of blood clots. However, the platelet count is usually interpreted in conjunction with other CBC parameters and clinical information to provide a more comprehensive understanding of a patient’s health status.

What is the Platelet-to-large cell ratio (PLCR)?
Platelet-to-large cell ratio (PLCR): is a calculated value that can be derived from a complete blood count (CBC) test. It is calculated by dividing the platelet count by the count of large cells (mainly immature granulocytes, including metamyelocytes, myelocytes, and promyelocytes) in the blood sample, and then multiplying the result by 100. The normal range for PLCR may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 10% to 33%. A low PLCR value may indicate a high degree of large cell production, which can be seen in conditions such as infections, inflammation, and some types of leukemia. However, PLCR is usually interpreted in conjunction with other CBC parameters and clinical information to provide a more comprehensive understanding of a patient’s health status.

WHAT IS A PERIPHERAL BLOOD SMEAR (PBS)?

A peripheral blood smear (PBS): is a laboratory test that involves taking a drop of blood from a person’s fingertip or a vein and spreading it onto a glass slide. The slide is then stained and examined under a microscope by a medical technologist or pathologist to assess the morphology (size, shape, and structure) of different blood cells, including red blood cells, white blood cells, and platelets. A PBS is often ordered as a follow-up test when abnormalities are detected on a complete blood count (CBC) test, or when a doctor suspects a blood disorder or infection. PBS can provide important diagnostic information on a range of conditions such as anemia, infections, leukemia, and other hematological disorders.
What is Plateletcrit (PCT)?

Plateletcrit (PCT): is a laboratory test that measures the volume or proportion of platelets in a person’s blood. It is calculated by multiplying the platelet count by the mean platelet volume (MPV), which represents the average size of platelets in the blood. The normal range for PCT may vary depending on the laboratory and the individual’s age, sex, and other factors, but typically ranges from 0.108 to 0.282. PCT can be useful in evaluating bleeding and clotting disorders, as well as in monitoring platelet levels during treatment with anticoagulants or antiplatelet drugs. However, PCT is usually interpreted in conjunction with other CBC parameters and clinical information to provide a more comprehensive understanding of a patient’s health status.

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In short, we can say the CBC Blood test is cover many infections in our body in short summary: 

CBC blood test depends on the values of its various components and the individual’s clinical context. Here is a brief overview of how the different CBC components are typically used to assess a patient’s health status:

  • Red blood cell (RBC) count, hemoglobin (Hb), and hematocrit (Hct) are used to evaluate a person’s oxygen-carrying capacity and can indicate conditions such as anemia or polycythemia.
  • White blood cell (WBC) count, along with the differential counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils, can provide information about a person’s immune system function and the presence of infections, inflammation, or certain types of cancer.
  • Platelet count, mean platelet volume (MPV), and platelet crit (PCT) can help assess a person’s risk of bleeding or clotting disorders and the effectiveness of anticoagulant or antiplatelet therapies.
  • Other parameters, such as mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW), can provide additional information about RBC size and shape, which can be useful in diagnosing various types of anemia.

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